Biggest stock movers Thursday: TSM, UAL, and more

Stock futures were mixed during Thursday’s premarket hours following President Donald Trump’s denial that he planned to fire Jerome Powell from his role as Federal Reserve chairman, though he did not entirely rule out Powell’s potential ouster.

Here are some of Thursday’s biggest stock movers:

Biggest stock gainers

• Sarepta Therapeutics (NASDAQ:SRPT) +31% — Shares surged after the company announced a strategic review that includes a 36% workforce reduction (~500 jobs) and a sharp refocus of its pipeline, including prioritization of siRNA platform assets. Sarepta aims to cut operating expenses by ~$400M annually, with $100M in savings expected by end-2025 and $300M in non-personnel savings from 2026.
• Taiwan Semiconductor Manufacturing (NYSE:TSM) +4% — Shares rose after the company released mixed Q2 results, which saw it surpass EPS expectations but miss on revenue, despite achieving robust Y/Y growth of 38.6%. Looking ahead, the company provided Q3 revenue guidance in the range of $31.8B to $33B, with a midpoint of $32.4B, exceeding the consensus estimate of $31.84B.

Biggest stock losers

• United Airlines (NASDAQ:UAL) -3% — Shares declined as a bottom-line beat was overshadowed by a top-line miss and narrower profit margins. Flight disruptions at Newark Liberty International Airport significantly impacted the company, with its second-quarter adjusted gross margin decreasing by 110 basis points to 11.0%. Looking to the current quarter, United anticipates continued profitability pressure from the Newark disruptions, forecasting earnings per share between $2.25 and $2.75, which straddles the $2.58 consensus. For fiscal year 2025, the airline projects a profit of $9 to $11 per share, compared to the $10.14 estimate, a notable adjustment from its previous quarter’s dual guidance of $7-$9 per share for a recessionary environment and $11.50-$13.50 per share for a stable economic environment.