Anavex, Cassava Sciences, Panax Ginseng, And The Long-Term Treatment Of Alzheimer’s Disease

Summary:

• Panax ginseng shows the highest effectiveness in treating Alzheimer’s because it inhibits nitro-oxidative stress, scavenges peroxynitrite, and reverses part of its damage, leading to sustained cognitive improvements over two years.
• Anavex’s Blarcamesine may slow mild Alzheimer’s progression due to its antioxidant capacity, with results from a 96-week trial potentially aiding regulatory approval.
• Cassava Sciences’ Simufilam’s effectiveness is limited to one year for mild Alzheimer’s, with no residual effects after discontinuation, and mixed results in combined mild and moderate groups.
• Safety profiles differ, with simufilam being safer but less effective long-term compared to blarcamesine. The latter may cause confusion and dizziness.

The inflammatory mediator peroxynitrite, when generated in excess, may damage cells by oxidizing and nitrating cellular components. Defense against this reactive species may be at the level of prevention of the formation of peroxynitrite, at the level of interception, or at the level

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